CXCR3 抗体
Quick Overview for CXCR3 抗体 (ABIN7673000)
抗原
See all CXCR3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- CXCR3-specific antibody
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纯化方法
- Protein A+G purification
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
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Immunogen sequence: peptide(N-terminal,extracellular domain)
Immunogen: chemokine(C-X-C motif) receptor 3
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亚型
- IgG1
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应用备注
- WB: 1:500-1:5000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
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有效期
- 12 months
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- CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))
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别名
- CXCR3
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背景
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Synonyms: C-X-C chemokine receptor type 3 (CXC-R3, CXCR-3)|CKR-L2|G protein-coupled receptor 9|Interferon-inducible protein 10 receptor (IP-10 receptor)|CXCR3|GPR9
Background: CXCR3(C-X-C chemokine receptor type 3) is a G protein-coupled, seven-transmembrane domain chemokine receptor that is expressed on the surface of a number of cell types, including activated CD4+ and CD8+ T cells, NK and NK-T cells, plasmacytoid dendritic cells, and some B cells(PMID: 16847335). CXCR3 binds and is activated by the three IFN-gamma-inducible chemokines: CXCL9, CXCL10, and CXCL11. Binding of these ligands to CXCR3 has been implicated in regulating T-cell infiltration during inflammation and tissue injury(PMID: 17250586). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms, CXCR3B, mediates the angiostatic activity of CXCR3 ligands and also acts as functional receptor for CXCL4(PMID:12782716). This monoclonal antibody is specific to CXCR3B.
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分子量
- 40 kDa+43 kDa
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基因ID
- 2833
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UniProt
- P49682
抗原
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